1/f noise in magnetic Ni80Fe20 single layers and Ni80Fe20/Cu multilayers

We have investigated the room temperature 1/f noise of microstructured soft magnetic Ni80Fe20 films, showing the anisotropic magnetoresistance effect, and of Ni80Fe20/Cu magnetic multilayers, showing the giant magnetoresistance effect. We find that the 1/f noise in magnetic multilayers is considerably enhanced with respect to the noise of the single domain layer, which sets a limit on the usability of giant magnetoresistance materials for low-frequency applications

Interface intermixing and magnetoresistance in Co/Cu spin valves with uncoupled Co layers

The interpretation of experiments on the effect of interface intermixing on the giant magnetoresistance (GMR) effect in antiferromagnetic-coupled multilayers can be complicated by the fact that interface intermixing also changes the coupling strength; therefore, we have grown an artificially intermixed region in Co/Cu spin valves with uncoupled Co layers. The structure we used was a newly engineered spin valve composed of 100 Å Co+6 Å Ru+25 Å Co+40 Å Cu+100 Å Co. Here the Ru layer provides an antiparallel alignment of the Co layers and the Cu layer decouples the upper two Co layers. An intermixed CoCu region has been grown at the Cu/Co interface and in some cases also at the Co/Cu interface by alternately sputtering 1 Å Co and 1 Å Cu. X-ray measurements confirm the existence of an intermixed region, although no reduction of magnetic moment is observed as is reported for homogeneous sputtered Co0.5Cu0.5 alloys. This indicates the existence of Co clusters in the intermixed regions. There is no difference in GMR between an intermixed layer of thickness t at one Co/Cu interface or two intermixed layers of thickness t/2 at both Co/Cu interfaces. Thus, it seems that the total thickness of the intermixed regions is decisive for the magnitude of the GMR. Because G, ¿G, and ¿G/Gap all show a gradual decrease when the nominal thickness of the intermixed region increases from 0 to 36 Å, this indicates that there is no strong spin-dependent scattering in this region. This is in agreement with calculations on a model bilayer Co/Cu/Co with the Camley–Barnas model

Spintronics: Fundamentals and applications

Spintronics, or spin electronics, involves the study of active control and manipulation of spin degrees of freedom in solid-state systems. This article reviews the current status of this subject, including both recent advances and well-established results. The primary focus is on the basic physical principles underlying the generation of carrier spin polarization, spin dynamics, and spin-polarized transport in semiconductors and metals. Spin transport differs from charge transport in that spin is a nonconserved quantity in solids due to spin-orbit and hyperfine coupling. The authors discuss in detail spin decoherence mechanisms in metals and semiconductors. Various theories of spin injection and spin-polarized transport are applied to hybrid structures relevant to spin-based devices and fundamental studies of materials properties. Experimental work is reviewed with the emphasis on projected applications, in which external electric and magnetic fields and illumination by light will be used to control spin and charge dynamics to create new functionalities not feasible or ineffective with conventional electronics.Comment: invited review, 36 figures, 900+ references; minor stylistic changes from the published versio

Depth Profiling Photoelectron-Spectroscopic Study of an Organic Spin Valve with a Plasma-Modified Pentacene Spacer

[[abstract]]We report an enhanced magnetoresistance (MR) in an organic spin valve with an oxygen plasma-treated pentacene (PC) spacer. The spin valve containing PC without the treatment shows no MR effect, whereas those with moderately plasma-treated PC exhibit MR ratios up to 1.64% at room temperature. X-ray photoelectron spectroscopy with depth profiling is utilized to characterize the interfacial electronic properties of the plasma-treated PC spacer which shows the formation of a derivative oxide layer. The results suggest an alternative approach to improve the interface quality and in turn to enhance the MR performance in organic spin valves.[[incitationindex]]SCI[[booktype]]電子

NIST interlaboratory study on glycosylation analysis of monoclonal antibodies : comparison of results from diverse analytical methods

Glycosylation is a topic of intense current interest in the development of biopharmaceuticals since it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy‑six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation  analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type.. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods